New research indicates that people who stop using blockbuster weight-loss injections like Wegovy and Mounjaro may regain shed pounds at a significantly accelerated pace than those who stop conventional lifestyle programs.
Published data in a prominent medical journal demonstrates that while overweight people often shed a large proportion of their body weight while undergoing treatment, the mass returns at an average rate of 0.8 kg per month once they quit.
"Users using such medications need to be informed of the danger of rapid weight regain when the treatment is stopped," warns lead investigator Dr. Susan Jebb.
That rate of recovery implies a return to pre-treatment weight within about 18 months.
Analyzing Therapies
The study, which reviewed dozens of trials involving thousands of participants, contrasted the effects of these new drugs with conventional dieting.
Researchers point out that individuals who lose weight through diet and exercise typically see a more gradual creep back—approximately 0.1 kg a month—once they finish.
Understanding the Rapid Regain
Experts suggest the way of the injections is key to understanding the accelerated regain.
GLP-1 drugs imitate a body's own chemical called GLP-1, which moderates hunger.
"Sustained high doses of GLP-1 concentrations several times higher than the body's typical production may cause the system to produce less of its endogenous hormone, and could reduce responsiveness to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this hormone supplement leads to appetite is uncontrolled, making overeating much more probable."
A Lifelong Disease?
Health authorities advise the injections for people with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Many experts argue that, considering the likelihood of relapse, the therapy should be considered long-term.
This opinion is supported by pharmaceutical companies, who note that the results "emphasize the long-term character of excess weight," comparing it to managing conditions like high blood pressure.
Patient Accounts
Users who have discontinued the jabs describe a sudden return of cravings.
"I experienced a trigger activating and I was suddenly ravenous," described one woman.
The struggle is compounded if patients have not developed permanent lifestyle or habit modifications during treatment.
Widespread Use
Survey data suggest that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with desire continuing to grow.
- Use is higher among females compared to men.
- The middle-aged age group shows the greatest level of interest.
- A large proportion obtain the drugs through private healthcare rather than public health services.
In conclusion, clinicians emphasize that while these medications are effective agents for weight loss, they are not a magic fix and long-term success relies on ongoing behavioural support.
